What's on the label is the measured result — net peptide mass, not gross powder weight, plus RP-HPLC purity, on a lot-numbered COA for every batch.
Net peptide mass and RP-HPLC purity — a lot-numbered COA for every batch.
Net peptide mass + HPLC purity, per lot.
PCAC will review 7 peptides for the 503A bulks list, BPC-157, KPV, TB-500, MOTS-c, Emideltide, Semax, Epitalon. Read our briefing →
PCAC will review 7 peptides for the 503A bulks list. Read →
FDA PCAC reviews 7 peptides in July. Read →
μ-opioid heptapeptide (D-Ala²) · analgesia research reference
Overview
Dermorphin is a naturally occurring opioid heptapeptide first isolated from the skin of South American Phyllomedusa frogs. Its defining feature is a D-alanine at position 2 — one of the earliest known examples of a ribosomally-derived vertebrate peptide bearing a D-amino acid — and that single stereochemical inversion is what gives dermorphin both its resistance to peptidase degradation and its very high affinity and selectivity for the μ-opioid receptor. In research it serves as a potent, selective μ-agonist tool for opioid-receptor pharmacology and peptide-transport questions. PeptideXpo supplies dermorphin as a lyophilized acetate at ≥ 98% HPLC, with the D-Ala² stereochemistry confirmed on the released lot — the specification that separates authentic dermorphin from an all-L mis-synthesis, and the line worth checking on any COA. The peptide is water-soluble and stable as a lyophilizate; reconstituted stocks should be aliquoted and kept frozen. Standard 2-10 mg fills cover receptor-binding and behavioral-model scales. Supplied as a research reference material only.
Who buys this, and why
Cognitive and neuropeptide buyers are predominantly research labs running in vivo rodent studies. The dominant administration route in the literature is intranasal, these peptides are not meaningfully blood-brain-barrier permeable when delivered systemically. For in vivo workflows, endotoxin and microbial-limit testing is recommended at the COA stage so the bioassay readout is not confounded by contamination unrelated to the test article.
Primary buyer fit: academic and contract research laboratories.
Specifications
Documentation available on request
Regulatory note
Research-use-only reference material; not for human or veterinary use.
Selected literature
Frequently asked questions
Natural ribosomal synthesis builds L-amino-acid peptides, so a D-residue is unusual and consequential. In dermorphin the D-Ala at position 2 blocks the aminopeptidase cleavage that would rapidly destroy an all-L sequence, and it locks the backbone into the conformation that binds the μ-opioid receptor with high affinity and selectivity. An accidentally all-L version of the same sequence is a different, far less active molecule — which is why stereochemical confirmation belongs on the COA.
Dermorphin is used as a selective μ-opioid-receptor agonist tool in receptor-pharmacology and analgesia research, and as a model substrate in studies of D-amino-acid peptide stability and blood-brain-barrier peptide transport. It has also featured in sports-integrity analytical work as a target analyte. PeptideXpo supplies it strictly as a research reference material.
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