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IGF-1 Ec splice-variant peptide
Supply and ordering
Ask sales about MGF availability, order quantities, packaging, and batch documentation. Include other catalog items in the same inquiry if you are planning a combined or recurring order.
Overview
MGF (Mechano Growth Factor) is a 24-amino-acid C-terminal peptide derived from the IGF-1 Ec splice variant, an alternative splicing of the IGF-1 gene that produces an E-domain extension distinct from the more commonly characterized IGF-1Ea form. Mechanical loading and exercise stress in skeletal muscle preferentially induce the Ec splice variant, hence the name 'Mechano Growth Factor'. The C-terminal E-peptide is hypothesized to act through a receptor distinct from the classical IGF-1 receptor and to drive satellite-cell proliferation in muscle-repair research models. PeptideXpo supplies unmodified MGF (the synthetic C-terminal E-peptide rather than the full IGF-1 Ec protein) as a lyophilized 2 mg vial to a ≥99.0% HPLC purity specification. The molecule is exceptionally short-lived in plasma (minutes), which is why PEGylated MGF is the more commonly used commercial form for in vivo research workflows. Unmodified MGF is appropriate for cell-culture studies of MGF biology where the short half-life is not a limitation. Sequence verification by LC-MS/MS is available when required by a written analytical scope because MGF's sequence overlap with IGF-1 means cross-supplier identity confirmation requires explicit sequencing rather than mass-alone confirmation.
Who buys this, and why
GH-axis peptides ship to two main buyer types: compounding pharmacies dispensing under physician supervision, and research labs studying somatotropic-axis pharmacology. Pharmacies typically want sterile-filled vials with the full release packet (sterility, endotoxin, CCI); labs typically want bulk lyophilized powder with sequence verification. Blends (the CJC-1295 / Ipamorelin combination is the canonical example) are usually co-lyophilized rather than solution-mixed for potency stability.
Primary buyer fit: academic and contract research laboratories.
Specifications
Documentation available on request
Each picture is a low-resolution preview of a report's first page, with batch and report numbers covered. For the full, clear report, ask our sales team, naming the product and strength.
Batch COAMGF 2 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Independent test fails? Full refund. How it works
Regulatory note
CAS for unmodified MGF is not consistently standardized across suppliers; confirm sequence and PEG status (if any, unmodified MGF should not have PEG) via batch COA.
Selected literature
Frequently asked questions
IGF-1 (Insulin-like Growth Factor 1) is the full-length 70-amino-acid mature growth factor expressed primarily by the liver in response to growth hormone signaling. MGF (Mechano Growth Factor) is a 24-amino-acid C-terminal peptide derived from a splice variant of the IGF-1 gene (the IGF-1Ec splice variant) that is preferentially induced in skeletal muscle by mechanical loading. The C-terminal E-peptide is the part that distinguishes MGF from the more commonly characterized IGF-1Ea form, and is hypothesized to act through a receptor distinct from the classical IGF-1 receptor. Practically: IGF-1 LR3 is the right tool for studying IGF-1 receptor pharmacology; MGF is the right tool for studying the E-peptide-specific satellite-cell signaling that drives muscle repair.
Unmodified MGF has an exceptionally short plasma half-life (minutes), making it impractical for any in vivo workflow that requires sustained exposure across hours or days. The very short half-life is biologically appropriate, MGF is intended to be a local autocrine/paracrine signal in muscle tissue, not a systemic hormone, but it limits the molecule's use in research contexts requiring controlled dosing. PEG-MGF (the PEGylated form) was developed specifically to extend the functional half-life and is the more commonly used form for in vivo work. Unmodified MGF is appropriate for cell-culture and short-duration biochemical assays where the minutes-scale stability is sufficient.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
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