MGF (Mechano Growth Factor)

PeptideXpo buyer fit

Overview

MGF (Mechano Growth Factor) is a 24-amino-acid C-terminal peptide derived from the IGF-1 Ec splice variant, an alternative splicing of the IGF-1 gene that produces an E-domain extension distinct from the more commonly characterized IGF-1Ea form. Mechanical loading and exercise stress in skeletal muscle preferentially induce the Ec splice variant, hence the name 'Mechano Growth Factor'. The C-terminal E-peptide is hypothesized to act through a receptor distinct from the classical IGF-1 receptor and to drive satellite-cell proliferation in muscle-repair research models. PeptideXpo supplies unmodified MGF (the synthetic C-terminal E-peptide rather than the full IGF-1 Ec protein) as a lyophilized 2 mg vial at ≥99.0% HPLC purity. The molecule is exceptionally short-lived in plasma (minutes), which is why PEGylated MGF is the more commonly used commercial form for in vivo research workflows. Unmodified MGF is appropriate for cell-culture studies of MGF biology where the short half-life is not a limitation. Sequence verification by LC-MS/MS is available when required by a written analytical scope because MGF's sequence overlap with IGF-1 means cross-supplier identity confirmation requires explicit sequencing rather than mass-alone confirmation.

Who buys this, and why

GH-axis peptides ship to two main buyer types: compounding pharmacies dispensing under physician supervision, and research labs studying somatotropic-axis pharmacology. Pharmacies typically want sterile-filled vials with the full release packet (sterility, endotoxin, CCI); labs typically want bulk lyophilized powder with sequence verification. Blends (the CJC-1295 / Ipamorelin combination is the canonical example) are usually co-lyophilized rather than solution-mixed for potency stability.

Primary buyer fit: academic and contract research laboratories.

Specifications

CAS

Not consistently registered; see batch COA

Purity (HPLC)

≥ 99.0%

Strength

2 mg

Packaging

10 vials/box · base pack (multiples of 10)

Half-life

≈ 5-7 minutes

MOQ

On request

Lead time

14–21 days

Storage

2–8°C, protect from light

Documentation available on request

• Certificate of Analysis (COA)
• HPLC Chromatogram
• Mass-spec identity (ESI-MS)
• Counter-ion (acetate vs TFA)
• Sterile-fill release pack (sterility, CCI, fill-weight)
• Bacterial endotoxin (LAL, USP <85>)
• Stability data on request
• SDS / MSDS

Regulatory note

CAS for unmodified MGF is not consistently standardized across suppliers; confirm sequence and PEG status (if any, unmodified MGF should not have PEG) via batch COA.

Selected literature

1. Goldspink G. Mechanical signals, IGF-I gene splicing, and muscle adaptation. Physiology (Bethesda). 2005;20:232-238.
2. Philippou A, Papageorgiou E, Bogdanis G, et al. Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: characterization of the MGF E peptide actions in vitro. In Vivo. 2009;23(4):567-575.
3. Carpenter V, Matthews K, Devlin G, et al. Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart Lung Circ. 2008;17(1):33-39.
4. Kandalla PK, Goldspink G, Butler-Browne G, Mouly V. Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages. Mech Ageing Dev. 2011;132(4):154-162.
5. Fornaro M, Hinken AC, Needle S, et al. Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells. Am J Physiol Endocrinol Metab. 2014;306(2):E150-E156.
6. Schlegel W, Raimann A, Halbauer D, et al. Insulin-Like Growth Factor I (IGF-1) Ec/Mechano Growth Factor – A Splice Variant of IGF-1 within the Growth Plate. PLoS One. 2013;8(10):e76133.

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