What's on the label is the measured result — net peptide mass, not gross powder weight, plus RP-HPLC purity, on a lot-numbered COA for every batch.
Net peptide mass and RP-HPLC purity — a lot-numbered COA for every batch.
Net peptide mass + HPLC purity, per lot.
PCAC will review 7 peptides for the 503A bulks list, BPC-157, KPV, TB-500, MOTS-c, Emideltide, Semax, Epitalon. Read our briefing →
PCAC will review 7 peptides for the 503A bulks list. Read →
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Spadin-derived TREK-1 blocker heptapeptide · mood research
Overview
PE-22-28 is a synthetic heptapeptide (Gly-Val-Ser-Trp-Gly-Leu-Arg) corresponding to the active core of spadin, a natural propeptide fragment released during sortilin (neurotensin receptor-3) maturation. Its research interest is as a selective blocker of the TREK-1 two-pore-domain potassium channel — a target implicated in mood regulation, where TREK-1 inhibition is associated in animal models with rapid antidepressant-like effects. PE-22-28 is studied as a shorter, more synthetically tractable tool than full-length spadin for probing that pathway. PeptideXpo supplies PE-22-28 as a lyophilized powder at ≥ 98% HPLC. As a small hydrophilic heptapeptide it reconstitutes readily in aqueous buffer; as with other short neuropeptides, aliquot and freeze to avoid repeated thaw cycles, and where CNS exposure is the research question note that the published work relies on parenteral rather than oral delivery. Standard 2-10 mg fills cover receptor-assay and behavioral-model scales. Supplied as a research reference material only.
Who buys this, and why
Cognitive and neuropeptide buyers are predominantly research labs running in vivo rodent studies. The dominant administration route in the literature is intranasal, these peptides are not meaningfully blood-brain-barrier permeable when delivered systemically. For in vivo workflows, endotoxin and microbial-limit testing is recommended at the COA stage so the bioassay readout is not confounded by contamination unrelated to the test article.
Primary buyer fit: academic and contract research laboratories.
Specifications
Documentation available on request
Regulatory note
Research-use-only reference material; not for human or veterinary use.
Selected literature
Frequently asked questions
TREK-1 is a two-pore-domain (K2P) potassium channel that helps set neuronal resting potential and excitability. Genetic deletion of TREK-1 produces a depression-resistant phenotype in animal models, which made pharmacological TREK-1 blockade an attractive rapid-antidepressant strategy. PE-22-28 is studied as a peptide tool that inhibits TREK-1, distinguishing it mechanistically from monoamine-based antidepressant research.
Spadin is a natural 17-residue propeptide fragment generated when sortilin (NTSR3) is processed. PE-22-28 is the 22-28 sub-fragment that retains the TREK-1-blocking activity in a shorter, easier-to-synthesize form — sometimes called 'mini-spadin.' For research it offers the same target engagement as spadin with simpler chemistry, which is why much of the tool-compound work has shifted to the shorter sequence.
