If a supplied lot fails agreed specifications, we’ll replace it at no cost or refund its purchase price in full.
Quality test failed? Free replacement or full refund.
Off-spec? Free replacement or full refund.
PCAC will review 7 peptides for the 503A bulks list, BPC-157, KPV, TB-500, MOTS-c, Emideltide, Semax, Epithalon. Read our briefing →
PCAC will review 7 peptides for the 503A bulks list. Read →
FDA PCAC reviews 7 peptides in July. Read →
Acetyl octapeptide-3 · cosmetic peptide
Supply and ordering
Compare SNAP-8 with Matrixyl, GHK-Cu, and related cosmetic peptides when planning a distributor or private-label order.
Overview
SNAP-8 (INCI: Acetyl Octapeptide-3) is a synthetic 8-amino-acid acetylated peptide designed as an extension of the original argireline (Acetyl Hexapeptide-3) molecule. The sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) is a mimetic of the N-terminal end of SNAP-25, the SNARE-complex protein involved in neurotransmitter vesicle docking. The mechanistic premise is competitive inhibition of SNAP-25 incorporation into the SNARE complex, which in vitro modulates neurotransmitter release at the neuromuscular junction, the cosmetic-finished-product use is in topical formulations targeting expression lines (forehead, glabellar, periocular). PeptideXpo supplies SNAP-8 to a ≥99.0% HPLC purity specification. Standard 10 mg and 100 mg lyophilized vials cover research-scale and small-format formulation work; kilo-scale orders for finished-product OEMs ship as bulk lyophilized powder with custom packaging. The cosmetic-grade specification sheet includes INCI name, CAS, water content, residual solvents, and microbial limits per cosmetic-pharmacopeia conventions. SNAP-8 is commonly co-formulated with Matrixyl (collagen-stimulating peptide) and GHK-Cu (copper-repair peptide) in multi-active anti-aging serum and cream formulations; PeptideXpo can supply standalone bulk material or finished-formulation OEM production through the OEM service.
Who buys this, and why
Cosmetic-peptide buyers fall into two groups: established beauty / med-aesthetic brands extending an existing line, and OEM clients building a private-label catalog from scratch. The first group usually wants bulk active plus stability data in their existing carrier matrix; the second usually wants a finished formulation under their label. Both need INCI naming verified, regulator-specific safety files (CPNP for EU, FDA OTC monograph for US where relevant), and packaging-compatibility data.
Primary buyer fit: medical aesthetic clinics and med spas and regional distributors and re-sellers.
Specifications
Also available as a nasal spray (US stock)
Besides lyophilized vials, SNAP-8 is stocked in the US as a ready-to-use nasal spray.
Documentation available on request
Each picture is a low-resolution preview of a report's first page, with batch and report numbers covered. For the full, clear report, ask our sales team, naming the product and strength.
Batch COASNAP-8 10 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Batch COASNAP-8 100 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Third-party reportSNAP-8 10 mg
HPLC purity · MS identity
Third-party laboratory, Tianjin, China
Full, clear copy from sales
Independent test fails? Full refund. How it works
Regulatory note
Sold as a cosmetic ingredient for use in finished products where the receiving formulator's regulatory framework permits. Finished-product safety, INCI compliance, claims substantiation, and notification (CPNP, FDA, etc.) remain the responsibility of the brand owner. SDS and INCI documentation available on request.
Selected literature
Frequently asked questions
SNAP-8 (Acetyl Octapeptide-3) is an 8-amino-acid extension of the original 6-amino-acid Argireline molecule, designed to extend the SNAP-25 mimetic interaction surface. In cosmetic formulation contexts, suppliers and finished-product brands sometimes claim SNAP-8 produces stronger or longer-lasting topical effects than Argireline at equivalent use levels, though peer-reviewed comparative data remains limited. Practically, both peptides are typically incorporated at 5-10% use level in finished serum or cream products and the choice between them is often a brand-positioning decision rather than a definitively-better choice. Stability profiles and formulation compatibilities are similar.
Typical use levels in published cosmetic formulations range from 3% to 10% of the finished product by mass, with most brands settling around 5-8%. Higher use levels do not produce proportionally larger effects in topical applications because the rate-limiting step is peptide penetration into the epidermis rather than the in vitro receptor-occupancy, so going above 10% generally adds cost without proportional benefit. Formulators should also account for SNAP-8's contribution to product cost, at typical bulk pricing the peptide can be a meaningful share of finished-product COGS at use levels above 5%.
Lyophilized SNAP-8 follows the standard 24-month re-test window at refrigerated storage. In finished cosmetic products, stability depends on the carrier system: aqueous serums maintain peptide stability well at neutral pH (5.5-7.0), while emulsions and high-water-activity creams require attention to microbial preservation because cosmetic peptides themselves do not provide preservation. Stability data in specific carrier matrices (typical serum, cream, ampoule formulations) can be developed as part of the OEM service for brands building a new finished product.
PeptideXpo supplies SNAP-8 (Acetyl Octapeptide-3, CAS 868844-74-0) as a cosmetic/research-grade lyophilized powder direct from the manufacturer. Standard fills are 10 mg and 100 mg, with kilo-scale available for finished-product OEMs; MOQ is on request and scales with format. A batch-specific Certificate of Analysis is available from sales for the offered or supplied lot. Ask our team for current bulk-pricing tiers and the COA for the lot we would allocate.
Yes. Ask sales for the batch COA matched to the offered or supplied SNAP-8 lot; it states the tests actually performed and their results. The batch COA reports RP-HPLC purity (≥99.0% specification) and mass-spec identity, traceable to the lot number on the vial; water content and counter-ion are available on request and listed on the COA when tested. A sample COA in our format is viewable before purchase; the clear, full-resolution certificate for the allocated lot is sent by our team on request.
Yes. Beyond bulk powder supply, PeptideXpo runs an OEM / private-label service: take SNAP-8 as standalone bulk for your own filling, or have us produce finished cosmetic formulations (serums, creams, ampoules) under your brand, commonly combining SNAP-8 with Matrixyl and GHK-Cu in multi-active anti-aging products. Contract-manufacturing scope, MOQs, and documentation (COA, INCI, SDS) are scoped per project.
Yes. SNAP-8 is also stocked as a ready-to-use nasal spray (10 mg) in 10 mL or 20 mL bottles, from 10 bottles of each. These orders ship from our US stock; ask our sales team for details and a quote.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
