What's on the label is the measured result — net peptide mass, not gross powder weight, plus RP-HPLC purity, on a lot-numbered COA for every batch.
Net peptide mass and RP-HPLC purity — a lot-numbered COA for every batch.
Net peptide mass + HPLC purity, per lot.
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Acetyl octapeptide-3 · cosmetic peptide
PeptideXpo buyer fit
This PeptideXpo page is for buyers comparing Snap-8 within a wider anti-aging peptide assortment. It should help a distributor, sourcing manager, or private-label buyer evaluate catalog adjacency, MOQ, COA readiness, and related SKUs before moving to a cosmetic-actives channel for finished-formulation and sample-packet work.
Overview
Snap-8 (INCI: Acetyl Octapeptide-3) is a synthetic 8-amino-acid acetylated peptide designed as an extension of the original argireline (Acetyl Hexapeptide-3) molecule. The sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) is a mimetic of the N-terminal end of SNAP-25, the SNARE-complex protein involved in neurotransmitter vesicle docking. The mechanistic premise is competitive inhibition of SNAP-25 incorporation into the SNARE complex, which in vitro modulates neurotransmitter release at the neuromuscular junction, the cosmetic-finished-product use is in topical formulations targeting expression lines (forehead, glabellar, periocular). PeptideXpo supplies Snap-8 at ≥99.0% HPLC purity. Standard 10 mg and 100 mg lyophilized vials cover research-scale and small-format formulation work; kilo-scale orders for finished-product OEMs ship as bulk lyophilized powder with custom packaging. The cosmetic-grade specification sheet includes INCI name, CAS, water content, residual solvents, and microbial limits per cosmetic-pharmacopeia conventions. Snap-8 is commonly co-formulated with Matrixyl (collagen-stimulating peptide) and GHK-Cu (copper-repair peptide) in multi-active anti-aging serum and cream formulations; PeptideXpo can supply standalone bulk material or finished-formulation OEM production through the OEM service.
Who buys this, and why
Cosmetic-peptide buyers fall into two groups: established beauty / med-aesthetic brands extending an existing line, and OEM clients building a private-label catalog from scratch. The first group usually wants bulk active plus stability data in their existing carrier matrix; the second usually wants a finished formulation under their label. Both need INCI naming verified, regulator-specific safety files (CPNP for EU, FDA OTC monograph for US where relevant), and packaging-compatibility data.
Primary buyer fit: medical aesthetic clinics and med spas and regional distributors and re-sellers.
Specifications
Documentation available on request
Regulatory note
Sold as a cosmetic ingredient for use in finished products where the receiving formulator's regulatory framework permits. Finished-product safety, INCI compliance, claims substantiation, and notification (CPNP, FDA, etc.) remain the responsibility of the brand owner. SDS and INCI documentation supplied with each shipment.
Frequently asked questions
Snap-8 (Acetyl Octapeptide-3) is an 8-amino-acid extension of the original 6-amino-acid Argireline molecule, designed to extend the SNAP-25 mimetic interaction surface. In cosmetic formulation contexts, suppliers and finished-product brands sometimes claim Snap-8 produces stronger or longer-lasting topical effects than Argireline at equivalent use levels, though peer-reviewed comparative data remains limited. Practically, both peptides are typically incorporated at 5-10% use level in finished serum or cream products and the choice between them is often a brand-positioning decision rather than a definitively-better choice. Stability profiles and formulation compatibilities are similar.
Typical use levels in published cosmetic formulations range from 3% to 10% of the finished product by mass, with most brands settling around 5-8%. Higher use levels do not produce proportionally larger effects in topical applications because the rate-limiting step is peptide penetration into the epidermis rather than the in vitro receptor-occupancy, so going above 10% generally adds cost without proportional benefit. Formulators should also account for Snap-8's contribution to product cost, at typical bulk pricing the peptide can be a meaningful share of finished-product COGS at use levels above 5%.
Lyophilized Snap-8 follows the standard 24-month re-test window at refrigerated storage. In finished cosmetic products, stability depends on the carrier system: aqueous serums maintain peptide stability well at neutral pH (5.5-7.0), while emulsions and high-water-activity creams require attention to microbial preservation because cosmetic peptides themselves do not provide preservation. Stability data in specific carrier matrices (typical serum, cream, ampoule formulations) can be developed as part of the OEM service for brands building a new finished product.
PeptideXpo supplies Snap-8 (Acetyl Octapeptide-3, CAS 868844-74-0) as a cosmetic/research-grade lyophilized powder direct from the manufacturer. Standard fills are 10 mg and 100 mg, with kilo-scale available for finished-product OEMs; MOQ is on request and scales with format. Every order ships with a batch-specific Certificate of Analysis. Ask our team for current bulk-pricing tiers and the COA for the lot we would allocate.
Yes. Every Snap-8 lot ships with a batch-specific COA covering RP-HPLC purity (>= 99.0% specification), mass-spec identity, water content, and counter-ion, traceable to the lot number on the vial. A sample COA in our format is viewable before purchase; the clear, full-resolution certificate for the allocated lot is sent by our team on request.
Yes. Beyond bulk powder supply, PeptideXpo runs an OEM / private-label service: take Snap-8 as standalone bulk for your own filling, or have us produce finished cosmetic formulations (serums, creams, ampoules) under your brand, commonly combining Snap-8 with Matrixyl and GHK-Cu in multi-active anti-aging products. Contract-manufacturing scope, MOQs, and documentation (COA, INCI, SDS) are scoped per project.
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