What's on the label is the measured result — net peptide mass, not gross powder weight, plus RP-HPLC purity, on a lot-numbered COA for every batch.
Net peptide mass and RP-HPLC purity — a lot-numbered COA for every batch.
Net peptide mass + HPLC purity, per lot.
PCAC will review 7 peptides for the 503A bulks list, BPC-157, KPV, TB-500, MOTS-c, Emideltide, Semax, Epitalon. Read our briefing →
PCAC will review 7 peptides for the 503A bulks list. Read →
FDA PCAC reviews 7 peptides in July. Read →
Corticotropin (1-39) · HPA-axis research peptide
Overview
ACTH (1-39), or corticotropin, is the complete 39-residue melanocortin peptide released from the anterior pituitary after proopiomelanocortin (POMC) processing. It is the primary secretagogue of the hypothalamic-pituitary-adrenal (HPA) axis: binding the melanocortin-2 receptor on the adrenal cortex drives steroidogenesis and the release of cortisol and other glucocorticoids. Because essentially all of the receptor-activating potency lives in the first 24 residues, ACTH (1-39) research overlaps with the shorter ACTH (1-24)/tetracosactide tool compounds, but the full-length sequence remains the reference form for adrenal-responsiveness and POMC-processing studies. PeptideXpo supplies human-sequence ACTH (1-39) as a lyophilized acetate salt at ≥ 98% HPLC. The peptide is sensitive to oxidation at its methionine residues and to surface adsorption at the low working concentrations typical of adrenal-cell assays, so buyers should reconstitute in a low-binding or carrier-protein vehicle and aliquot to avoid freeze-thaw cycling. Porcine and rat/mouse sequences differ from the human form in the C-terminal region — specify the species context whenever the readout depends on receptor- or epitope-species matching. Supplied as a research reference material only.
Specifications
Documentation available on request
Regulatory note
Research-use-only reference material; not for human or veterinary use.
Selected literature
Frequently asked questions
The receptor-activating pharmacophore of ACTH lives in the N-terminal 1-24 segment, which is why the synthetic ACTH (1-24) analog (tetracosactide/cosyntropin) reproduces the adrenal-stimulating activity used in clinical adrenal-reserve testing. ACTH (1-39) is the full endogenous sequence; its C-terminal 25-39 residues shape binding kinetics and metabolic/antigenic behavior rather than raw potency. For POMC-processing, immunoassay-standard, and species-comparison work the full-length form is the appropriate reference; for pure MC2R-activation assays the 1-24 fragment is often used interchangeably.
The 39-residue sequence is not identical across species, with most variation in the C-terminal region. For MC2R-activation studies those differences are usually tolerated, but for immunoassays, antibody-based detection, or any experiment whose readout depends on exact epitope matching, the wrong species sequence introduces error. PeptideXpo's standard SKU is the human sequence; other species sequences are available through the OEM synthesis service.
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