What's on the label is the measured result — net peptide mass, not gross powder weight, plus RP-HPLC purity, on a lot-numbered COA for every batch.
Net peptide mass and RP-HPLC purity — a lot-numbered COA for every batch.
Net peptide mass + HPLC purity, per lot.
PCAC will review 7 peptides for the 503A bulks list, BPC-157, KPV, TB-500, MOTS-c, Emideltide, Semax, Epitalon. Read our briefing →
PCAC will review 7 peptides for the 503A bulks list. Read →
FDA PCAC reviews 7 peptides in July. Read →
Synthetic GnRH/LHRH decapeptide (acetate) · HPG-axis research
Overview
Gonadorelin is the synthetic form of native gonadotropin-releasing hormone (GnRH/LHRH), the hypothalamic decapeptide at the top of the reproductive endocrine axis. Delivered in a pulsatile pattern it stimulates the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH); delivered continuously it paradoxically desensitizes the same receptors — the on/off distinction that defines GnRH pharmacology and separates the native decapeptide from the long-acting superagonist analogs. PeptideXpo supplies the acetate salt, the form used in most research and compounding contexts. Gonadorelin acetate ships as a lyophilized powder at ≥ 98% HPLC. Its native sequence gives it a short functional half-life, which is precisely why the research literature emphasizes pulsatile rather than steady-state exposure — buyers modeling physiological release should plan dosing intervals accordingly. Prepare in an isotonic vehicle, aliquot, and keep frozen to limit the aggregation short GnRH peptides can show on repeated freeze-thaw. Standard 2 mg and 5 mg fills cover typical research and compounding-pharmacy scales. Supplied as a research reference material.
Specifications
Documentation available on request
Regulatory note
Research-use-only reference material; not for human or veterinary use.
Selected literature
Frequently asked questions
GnRH receptors on pituitary gonadotrophs respond to the pattern of exposure, not just the amount. Physiological pulsatile GnRH (roughly every 60-120 minutes) keeps the receptors responsive and drives LH/FSH secretion. Continuous, non-pulsatile exposure downregulates and desensitizes those receptors and shuts secretion down — the basis for how long-acting GnRH superagonists suppress the axis. Research designs that ignore the pulsatile requirement will not reproduce the physiological response.
Gonadorelin is the native GnRH decapeptide: short half-life, stimulatory, pulsatile pharmacology. Superagonists like leuprolide are stabilized analogs with long half-lives that, through continuous receptor occupancy, produce sustained suppression after an initial flare. They are effectively opposite tools — gonadorelin for stimulating or modeling normal axis function, superagonists for suppressing it.
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