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Quality test failed? Free replacement or full refund.
Off-spec? Free replacement or full refund.
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FSH / LH-active gonadotropin · heavily regulated
Supply and ordering
Ask sales about HMG availability, order quantities, packaging, and batch documentation. Include other catalog items in the same inquiry if you are planning a combined or recurring order.
Overview
Human Menopausal Gonadotropin (HMG, generic name Menotropins) is a mixed FSH and LH gonadotropin preparation purified from the urine of postmenopausal women, where elevated pituitary gonadotropins are excreted in concentrated form due to the loss of ovarian feedback inhibition. The historical material is a roughly 1:1 mixture of FSH and LH biological activity per IU and is approved for ovulation induction and assisted reproductive technology workflows under brand names including Menopur, Repronex, and several biosimilars. HMG occupies a distinct position in the gonadotropin category because the dual FSH+LH activity supports both follicular development and luteal-phase support, in contrast to recombinant FSH-only preparations (Gonal-F, Follistim) that require co-administration of an LH source. PeptideXpo distributes HMG only to qualified buyers with appropriate licensing for assisted-reproductive or compounding workflows in their destination jurisdiction. The 75 IU standard fill is the historical convention matching the classical Menopur ampoule format. Biological activity (FSH IU + LH IU per ampoule by bioassay) matters more than chemical purity alone, because the urine-derived source means the material is a mixed glycoprotein population rather than a defined single molecule; the batch COA reports HPLC purity and MS identity, and bioassay potency is available on request and listed on the COA when tested.
Specifications
Also available as a nasal spray (US stock)
Besides lyophilized vials, HMG is stocked in the US as a ready-to-use nasal spray.
Documentation available on request
Each picture is a low-resolution preview of a report's first page, with batch and report numbers covered. For the full, clear report, ask our sales team, naming the product and strength.
Batch COAHMG 75 iu
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Independent test fails? Full refund. How it works
Regulatory note
Highly regulated urine-derived gonadotropin biological. Sold only to qualified buyers with appropriate licensing in their jurisdiction. Order requires compliance review.
Selected literature
Frequently asked questions
HMG is a urine-derived mixed-gonadotropin preparation containing both FSH and LH activity in roughly 1:1 ratio per IU. Recombinant FSH preparations (Gonal-F, Follistim) contain only FSH activity, with no LH component. The clinical consequence is that HMG supports both follicular development (FSH-driven) and luteal-phase progesterone production (LH-driven) within a single product, whereas recombinant FSH protocols typically require separate LH-source administration during the luteal phase. The choice between HMG and recombinant FSH depends on the specific assisted-reproductive-technology protocol, patient population, and prescriber preference. Both are widely used and supported by extensive clinical data.
Urinary-derived HMG (under brand names Menopur, Repronex, and biosimilars) has been used clinically since the 1950s with extensive accumulated safety and efficacy data. The recombinant alternatives are more recent (1990s onwards) and offer the theoretical advantage of higher-purity material with consistent batch composition, but the clinical-outcome differences in most published comparison studies are modest. The urinary-derived preparations also have economic advantages, sourcing from postmenopausal-women urine remains less expensive per IU than recombinant cell-culture production. Many assisted-reproductive-technology centers continue to use HMG protocols specifically because of the depth of accumulated experience with the urinary-derived preparation.
The 75 IU fill follows the classical Menopur ampoule format, the historical unit of urinary gonadotropin preparations. Much of the gonadotropin-injection ecosystem, including inventory management at clinics and pharmacies, is built around this unit size, which is why the 75 IU ampoule remains the common format even where other fills exist. The fill states the nominal FSH and LH activity per vial; the batch COA reports HPLC purity and MS identity, and bioassay potency is available on request and listed on the COA when tested.
Yes. HMG is also stocked as a ready-to-use nasal spray (75 IU) in 10 mL or 20 mL bottles, from 10 bottles of each. These orders ship from our US stock; ask our sales team for details and a quote.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
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