What's on the label is the measured result — net peptide mass, not gross powder weight, plus RP-HPLC purity, on a lot-numbered COA for every batch.
Net peptide mass and RP-HPLC purity — a lot-numbered COA for every batch.
Net peptide mass + HPLC purity, per lot.
PCAC will review 7 peptides for the 503A bulks list, BPC-157, KPV, TB-500, MOTS-c, Emideltide, Semax, Epitalon. Read our briefing →
PCAC will review 7 peptides for the 503A bulks list. Read →
FDA PCAC reviews 7 peptides in July. Read →
Potent GHRP hexapeptide · GH-secretagogue research
Overview
Hexarelin (Examorelin) is a synthetic growth-hormone-releasing hexapeptide — a structurally optimized descendant of GHRP-6 and one of the most potent peptidic GH secretagogues characterized. It acts at the growth-hormone-secretagogue receptor (GHS-R1a, the ghrelin receptor) to trigger pulsatile pituitary GH release, and is separately studied for a partly GH-independent action at the CD36 scavenger receptor that underlies its cardiovascular research interest. PeptideXpo supplies the acetate salt used across GH-axis research. Hexarelin acetate ships as a lyophilized powder at ≥ 98% HPLC. Among the GHRP-family tools it stands out for high potency and, in the published literature, for faster receptor desensitization on continuous exposure than the milder secretagogues — buyers designing repeat-dose research should account for that tachyphylaxis when comparing it against GHRP-2, GHRP-6, or ipamorelin. Prepare in bacteriostatic or sterile water, aliquot, and store frozen. Standard 2 mg and 5 mg fills cover common research scales. Supplied as a research reference material only.
Who buys this, and why
GH-axis peptides ship to two main buyer types: compounding pharmacies dispensing under physician supervision, and research labs studying somatotropic-axis pharmacology. Pharmacies typically want sterile-filled vials with the full release packet (sterility, endotoxin, CCI); labs typically want bulk lyophilized powder with sequence verification. Blends (the CJC-1295 / Ipamorelin combination is the canonical example) are usually co-lyophilized rather than solution-mixed for potency stability.
Primary buyer fit: academic and contract research laboratories.
Specifications
Documentation available on request
Regulatory note
Research-use-only reference material; not for human or veterinary use.
Selected literature
Frequently asked questions
All four are GHS-R1a agonists that stimulate GH release, but they differ in potency, selectivity, and side-signal profile. Hexarelin is among the most potent and, unlike ipamorelin, is not fully selective — it can raise cortisol and prolactin at higher exposures and shows more pronounced desensitization on continuous dosing. Ipamorelin is the cleanest/most selective, GHRP-2 is potent with moderate selectivity, and GHRP-6 is the original with notable appetite stimulation. The right reference tool depends on whether the question needs maximum potency or clean selectivity.
In addition to GHS-R1a, hexarelin binds the scavenger receptor CD36, expressed in cardiac and vascular tissue. This second interaction is GH-independent and is the basis for the cardiovascular-research literature around hexarelin, distinct from its growth-hormone-secretagogue role — one reason it is studied as a pharmacological tool in contexts unrelated to the GH axis.
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