If a supplied lot fails agreed specifications, we’ll replace it at no cost or refund its purchase price in full.
Quality test failed? Free replacement or full refund.
Off-spec? Free replacement or full refund.
PCAC will review 7 peptides for the 503A bulks list, BPC-157, KPV, TB-500, MOTS-c, Emideltide, Semax, Epithalon. Read our briefing →
PCAC will review 7 peptides for the 503A bulks list. Read →
FDA PCAC reviews 7 peptides in July. Read →
Ghrelin / GHSR pathway GH-release peptide
Supply and ordering
Ask sales about Ipamorelin availability, order quantities, packaging, and batch documentation. Include other catalog items in the same inquiry if you are planning a combined or recurring order.
Overview
Ipamorelin is a synthetic 5-amino-acid pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) engineered as a highly selective GHSR (ghrelin / growth-hormone secretagogue receptor) agonist. Unlike the broader GHRP family (GHRP-2, GHRP-6, Hexarelin), Ipamorelin's selectivity for GHSR over the related receptors that regulate cortisol, prolactin, and ACTH release makes it the most clean GH-selective GHSR agonist in routine research use, the absence of cortisol-axis activation is the defining pharmacological feature relative to the older GHRP analogues. PeptideXpo supplies Ipamorelin acetate as a lyophilized powder to a ≥99.0% HPLC purity specification. The short sequence makes synthesis straightforward, and the analytical packet emphasizes peak-integration HPLC plus mass spec, sequence verification by LC-MS/MS is available on request but is rarely the critical test for a 5-residue peptide. Ipamorelin is most commonly combined with a GHRH-pathway agonist (CJC-1295 no-DAC, Sermorelin, or Tesamorelin) in dual-pathway research and compounding workflows; the canonical CJC-1295 + Ipamorelin blend is supplied pre-co-lyophilized under the cjc-1295-ipamorelin SKU at standard 5+5 mg ratios with custom ratios via OEM service. For the full pharmacology of the dual-pathway approach, see our CJC-1295 + Ipamorelin guide.
Who buys this, and why
GH-axis peptides ship to two main buyer types: compounding pharmacies dispensing under physician supervision, and research labs studying somatotropic-axis pharmacology. Pharmacies typically want sterile-filled vials with the full release packet (sterility, endotoxin, CCI); labs typically want bulk lyophilized powder with sequence verification. Blends (the CJC-1295 / Ipamorelin combination is the canonical example) are usually co-lyophilized rather than solution-mixed for potency stability.
Primary buyer fit: academic and contract research laboratories and 503A / 503B compounding pharmacies.
Specifications
Also available as a nasal spray (US stock)
Besides lyophilized vials, Ipamorelin is stocked in the US as a ready-to-use nasal spray.
Documentation available on request
Each picture is a low-resolution preview of a report's first page, with batch and report numbers covered. For the full, clear report, ask our sales team, naming the product and strength.
Batch COAIpamorelin 2 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Batch COAIpamorelin 5 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Batch COAIpamorelin 10 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Independent test fails? Full refund. How it works
Regulatory note
Sold as a bulk active for research and for compounding-pharmacy formulation where local regulations permit (notably 503A / 503B in the United States and analogous regimes elsewhere). Not a finished dosage form. Sterile-filled vials are available with full release documentation; the buyer is responsible for verifying scheduling and dispense requirements in the destination market.
Selected literature
Frequently asked questions
All three are GHSR (ghrelin receptor) agonists, but they differ in their selectivity profile. GHRP-2 and GHRP-6 also activate the receptors involved in cortisol release, prolactin secretion, and (for GHRP-6 especially) appetite stimulation, these off-target effects can confound research readouts and are clinically undesirable in compounding-pharmacy applications. Ipamorelin's pentapeptide design was specifically engineered to retain the GHSR-binding affinity while losing the cortisol-pathway activation, making it the cleanest GHSR-selective agonist in routine use. The trade-off is that GHRP-2 and GHRP-6 produce somewhat larger GH-release magnitudes; Ipamorelin produces a more selective but slightly smaller GH pulse.
Ipamorelin acts on the GHSR; CJC-1295 acts on the GHRH receptor. These are two parallel pathways converging on the same somatotroph cells, and combining a GHSR-pathway agonist with a GHRH-pathway agonist produces GH-release magnitudes substantially larger than either component alone at comparable individual doses. The standard combination ratio is 1:1 by mass (typically 5+5 mg per vial). For research workflows studying GHSR pharmacology in isolation, Ipamorelin alone is the appropriate choice; for GH-release-maximizing workflows, the dual-pathway combination is essentially universal.
Ipamorelin reconstitutes cleanly in bacteriostatic water for injection at typical research concentrations (1-5 mg/mL is common). The reconstituted solution is reasonably stable at -20 °C as single-use aliquots, but as with the rest of the GH-axis class, freeze-thaw cycling is the dominant source of measured-potency loss. The operational guidance is to split into the smallest workable aliquot volumes immediately after reconstitution and limit thaw cycles to three or fewer. The lyophilized product itself follows the standard 24-month re-test window at -20 °C.
Yes. Ipamorelin is also stocked as a ready-to-use nasal spray (2 mg, 5 mg, 10 mg) in 10 mL or 20 mL bottles, from 10 bottles of each. These orders ship from our US stock; ask our sales team for details and a quote.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
Related peptides
Modified GRF 1-29 · GHRH analog
Nasal spray available
29-mer
GHRH 1-29 fragment
Nasal spray availableCapsules available
GH-axis blend (CJC-1295 no DAC + Ipamorelin)
