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Off-spec? Free replacement or full refund.
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GHRH 1-29 fragment
Supply and ordering
Ask sales about Sermorelin availability, order quantities, packaging, and batch documentation. Include other catalog items in the same inquiry if you are planning a combined or recurring order.
Overview
Sermorelin is the unmodified 29-amino-acid N-terminal fragment of native human GHRH (residues 1-29), retaining the full receptor-binding activity of the parent 44-residue molecule. Approved historically as a prescription drug (Geref) for pediatric GH deficiency diagnosis, Sermorelin is the most studied GHRH-receptor agonist and serves as the reference compound against which engineered analogues (CJC-1295, Tesamorelin, Modified GRF 1-29) are compared. The molecule's clinical pharmacokinetic limitation, a serum half-life of roughly 10-12 minutes due to DPP-4 cleavage at the Tyr1-Ala2 bond, is the design problem that motivated the substitution chemistry behind the CJC-1295 family. PeptideXpo supplies Sermorelin acetate as a lyophilized powder to a ≥99.0% HPLC purity specification. The 29-residue sequence is within reliable SPPS range; every released lot comes with its batch COA covering peak-integration HPLC purity and ESI mass-spec identity, with water content and counter-ion available on request and listed on the COA when tested. Sermorelin is typically used in research contexts studying GHRH-receptor pharmacology at physiologically relevant time scales (the short half-life is a feature, not a bug, for pulse-pharmacology research) and in compounding workflows where the short-acting profile is appropriate. For sustained-action profiles, buyers generally route to CJC-1295 with DAC instead.
Who buys this, and why
GH-axis peptides ship to two main buyer types: compounding pharmacies dispensing under physician supervision, and research labs studying somatotropic-axis pharmacology. Pharmacies typically want sterile-filled vials with the full release packet (sterility, endotoxin, CCI); labs typically want bulk lyophilized powder with sequence verification. Blends (the CJC-1295 / Ipamorelin combination is the canonical example) are usually co-lyophilized rather than solution-mixed for potency stability.
Primary buyer fit: academic and contract research laboratories and 503A / 503B compounding pharmacies.
Specifications
Also available as a nasal spray (US stock)
Besides lyophilized vials, Sermorelin is stocked in the US as a ready-to-use nasal spray.
Capsules · US stock
Sermorelin is also supplied as capsules from our US stock.
Documentation available on request
Each picture is a low-resolution preview of a report's first page, with batch and report numbers covered. For the full, clear report, ask our sales team, naming the product and strength.
Batch COASermorelin 2 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Batch COASermorelin 5 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Batch COASermorelin 10 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Independent test fails? Full refund. How it works
Regulatory note
Sold as a bulk active for research and for compounding-pharmacy formulation where local regulations permit (notably 503A / 503B in the United States and analogous regimes elsewhere). Not a finished dosage form. Sterile-filled vials are available with full release documentation; the buyer is responsible for verifying scheduling and dispense requirements in the destination market.
Selected literature
Frequently asked questions
All three are GHRH-receptor agonists, but they differ in their pharmacokinetic engineering. Sermorelin is the unmodified GHRH(1-29) fragment with a roughly 10-minute serum half-life, the native molecule's properties. CJC-1295 (no DAC) adds four amino-acid substitutions that resist DPP-4 cleavage, extending half-life to roughly 30 minutes while retaining the physiological pulsatile signaling pattern. Tesamorelin adds an N-terminal trans-3-hexenoyl group, similarly improving protease resistance and extending half-life, Tesamorelin is the only FDA-approved member of this family, indicated for HIV-associated lipodystrophy. CJC-1295 with DAC sits at the far end of the half-life spectrum at roughly a week via albumin binding.
Research workflows studying GHRH-receptor pharmacology often need to characterize pulsatile signaling at physiologically relevant timescales, sustained-elevation models produce different downstream biology than pulse-pattern models because GH-release feedback loops respond to pulse architecture, not just average exposure. Sermorelin's short half-life makes it the cleanest tool for studying pulse-pharmacology, dose-response within a single GH pulse, and acute receptor pharmacology. For sustained-elevation research or for clinical contexts where convenience matters, the longer-acting CJC-1295 (no DAC) or CJC-1295 with DAC are preferred.
Yes, the GHRH-pathway plus GHSR-pathway combination strategy applies to Sermorelin the same way it applies to CJC-1295: combining a GHRH-receptor agonist with a GHSR agonist produces additive GH-release magnitudes beyond either component alone. The Sermorelin + Ipamorelin combination is less common than CJC-1295 + Ipamorelin in published research and compounding workflows simply because CJC-1295's longer half-life better matches Ipamorelin's, but for short-pulse research applications the Sermorelin combination is mechanistically equivalent.
Yes. Sermorelin is also stocked as a ready-to-use nasal spray (2 mg) in 10 mL or 20 mL bottles, from 10 bottles of each. These orders ship from our US stock; ask our sales team for details and a quote.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
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