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Metastin (45-54) · HPG-axis research peptide
Supply and ordering
Ask sales about Kisspeptin-10 availability, order quantities, packaging, and batch documentation. Include other catalog items in the same inquiry if you are planning a combined or recurring order.
Overview
Kisspeptin-10 (also known as Metastin 45-54 or KP-10) is the 10-amino-acid C-terminal fragment of the larger kisspeptin family of peptides encoded by the KISS1 gene. The decapeptide retains essentially all of the KISS1 receptor (GPR54)-binding activity of the longer family members (Kisspeptin-54, -14, -13). Kisspeptin signaling at the hypothalamic level is the master regulator of GnRH neuron activation, which in turn drives downstream pituitary LH and FSH release, making kisspeptin-10 the canonical research tool for studying the apex of the hypothalamic-pituitary-gonadal (HPG) axis. PeptideXpo supplies Kisspeptin-10 as a lyophilized powder to a ≥99.0% HPLC purity specification. The 10-residue sequence is straightforward in SPPS; every released lot comes with its batch COA covering peak-integration HPLC purity and mass-spec identity, with water content and counter-ion available on request and listed on the COA when tested. Sequence verification by LC-MS/MS is available on request. Buyers should note that Kisspeptin-10 has a relatively short plasma half-life (minutes) due to peptidase cleavage at the C-terminal RFamide motif, in vivo research protocols typically use continuous infusion or repeated bolus dosing to maintain HPG-axis stimulation, and intranasal preparations have been explored as a longer-duration alternative.
Specifications
Also available as a nasal spray (US stock)
Besides lyophilized vials, Kisspeptin-10 is stocked in the US as a ready-to-use nasal spray.
Documentation available on request
Each picture is a low-resolution preview of a report's first page, with batch and report numbers covered. For the full, clear report, ask our sales team, naming the product and strength.
Batch COAKisspeptin-10 5 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Batch COAKisspeptin-10 10 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Independent test fails? Full refund. How it works
Regulatory note
Sold as a bulk active for research and for compounding-pharmacy formulation where local regulations permit. Several items in this category (HMG, Oxytocin, PT-141 / Bremelanotide) are approved prescription hormones and are heavily regulated, supplied only to qualified buyers with appropriate licensing; orders require compliance review and may require import authorization for the destination market. Not a finished dosage form and not labeled for human administration as shipped.
Selected literature
Frequently asked questions
The KISS1 gene encodes a 145-amino-acid precursor that is processed into several biologically active C-terminal fragments: Kisspeptin-54 (the longest endogenous form, also called Metastin), Kisspeptin-14, Kisspeptin-13, and Kisspeptin-10. All four share the same C-terminal 10-amino-acid sequence ending in the RFamide motif that binds GPR54. Kisspeptin-10 retains essentially full binding activity at GPR54 and is the most commonly used research form because it's simpler to synthesize at high purity and avoids the variability that comes with longer-fragment processing. The longer forms (-54, -14) have slightly different pharmacokinetic profiles in vivo but similar receptor pharmacology.
Kisspeptin neurons in the hypothalamus (specifically in the arcuate nucleus and the rostral periventricular area) sit upstream of GnRH-releasing neurons. KISS1 signaling at GPR54 on GnRH neurons is the direct trigger for GnRH release into the hypophyseal portal system, which then drives pituitary LH and FSH release. In other words, kisspeptin is the proximate signal that determines whether the entire HPG cascade is active or quiescent, making it the master regulator of reproductive axis function. Disruption of kisspeptin signaling (loss-of-function mutations in KISS1 or GPR54) causes hypogonadotropic hypogonadism in humans, confirming the master-regulator role.
Yes. Kisspeptin-10 is also stocked as a ready-to-use nasal spray (10 mg) in 10 mL or 20 mL bottles, from 10 bottles of each. These orders ship from our US stock; ask our sales team for details and a quote.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
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