What's on the label is the measured result — net peptide mass, not gross powder weight, plus RP-HPLC purity, on a lot-numbered COA for every batch.
Net peptide mass and RP-HPLC purity — a lot-numbered COA for every batch.
Net peptide mass + HPLC purity, per lot.
PCAC will review 7 peptides for the 503A bulks list, BPC-157, KPV, TB-500, MOTS-c, Emideltide, Semax, Epitalon. Read our briefing →
PCAC will review 7 peptides for the 503A bulks list. Read →
FDA PCAC reviews 7 peptides in July. Read →
Metastin (45-54) · HPG-axis research peptide
PeptideXpo buyer fit
This PeptideXpo page is intentionally positioned for distributors, OEM buyers, and procurement teams comparing Kisspeptin-10 inside a wider peptide catalog. It is not trying to be the deepest single-molecule monograph; the differentiated intent is assortment planning, export-ready documentation, fill-size comparison, and whether this SKU belongs in a broader buyer program.
Overview
Kisspeptin-10 (also known as Metastin 45-54 or KP-10) is the 10-amino-acid C-terminal fragment of the larger kisspeptin family of peptides encoded by the KISS1 gene. The decapeptide retains essentially all of the KISS1 receptor (GPR54)-binding activity of the longer family members (Kisspeptin-54, -14, -13). Kisspeptin signaling at the hypothalamic level is the master regulator of GnRH neuron activation, which in turn drives downstream pituitary LH and FSH release, making kisspeptin-10 the canonical research tool for studying the apex of the hypothalamic-pituitary-gonadal (HPG) axis. PeptideXpo supplies Kisspeptin-10 as a lyophilized powder at ≥99.0% HPLC purity. The 10-residue sequence is straightforward in SPPS; the analytical packet covers peak-integration HPLC, mass spec, water content, and counter-ion. Sequence verification by LC-MS/MS is available on request. Buyers should note that Kisspeptin-10 has a relatively short plasma half-life (minutes) due to peptidase cleavage at the C-terminal RFamide motif, in vivo research protocols typically use continuous infusion or repeated bolus dosing to maintain HPG-axis stimulation, and intranasal preparations have been explored as a longer-duration alternative.
Specifications
Documentation available on request
Regulatory note
Sold as a bulk active for research and for compounding-pharmacy formulation where local regulations permit. Several items in this category (HCG, HMG, Oxytocin, PT-141 / Bremelanotide) are approved prescription hormones and are heavily regulated, supplied only to qualified buyers with appropriate licensing; orders require compliance review and may require import authorization for the destination market. Not a finished dosage form and not labeled for human administration as shipped.
Frequently asked questions
The KISS1 gene encodes a 145-amino-acid precursor that is processed into several biologically active C-terminal fragments: Kisspeptin-54 (the longest endogenous form, also called Metastin), Kisspeptin-14, Kisspeptin-13, and Kisspeptin-10. All four share the same C-terminal 10-amino-acid sequence ending in the RFamide motif that binds GPR54. Kisspeptin-10 retains essentially full binding activity at GPR54 and is the most commonly used research form because it's simpler to synthesize at high purity and avoids the variability that comes with longer-fragment processing. The longer forms (-54, -14) have slightly different pharmacokinetic profiles in vivo but similar receptor pharmacology.
Kisspeptin neurons in the hypothalamus (specifically in the arcuate nucleus and the rostral periventricular area) sit upstream of GnRH-releasing neurons. KISS1 signaling at GPR54 on GnRH neurons is the direct trigger for GnRH release into the hypophyseal portal system, which then drives pituitary LH and FSH release. In other words, kisspeptin is the proximate signal that determines whether the entire HPG cascade is active or quiescent, making it the master regulator of reproductive axis function. Disruption of kisspeptin signaling (loss-of-function mutations in KISS1 or GPR54) causes hypogonadotropic hypogonadism in humans, confirming the master-regulator role.
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