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Mitochondrial-targeted peptide
Supply and ordering
Ask sales about SS-31 / Elamipretide availability, order quantities, packaging, and batch documentation. Include other catalog items in the same inquiry if you are planning a combined or recurring order.
Overview
SS-31 (also known as Elamipretide, Bendavia, MTP-131) is a synthetic cationic-aromatic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH₂, where Dmt is 2',6'-dimethyl-L-tyrosine) engineered as a Szeto-Schiller (SS) peptide, a class of cell-permeable mitochondria-targeted peptides developed by Hazel Szeto. The cationic-aromatic pattern allows passive accumulation in the inner mitochondrial membrane driven by the negative membrane potential, where SS-31 binds cardiolipin and protects the lipid from peroxidative damage. The protection of cardiolipin in turn preserves the structural integrity of the cristae and the function of the OXPHOS supercomplexes, the mechanistic basis for SS-31's clinical-development program in mitochondrial dysfunction disorders (Barth syndrome, primary mitochondrial myopathies) and acute-injury contexts (ischemia-reperfusion injury, contrast-induced nephropathy). PeptideXpo supplies SS-31 acetate as a lyophilized powder to a ≥99.0% HPLC purity specification. The Dmt (2',6'-dimethyltyrosine) residue is non-natural and requires specialized Fmoc-protected building blocks, the analytical packet includes mass spec confirming the modified mass and is the diagnostic identity check at +28 Da relative to the natural-Tyr analog. Sequence verification by LC-MS/MS is available when required by a written analytical scope because Dmt-substituted peptides can have similar retention to unmodified analogs that are biologically inactive. Three fill sizes (5, 10, 50 mg) cover most research and compounding workflows.
Who buys this, and why
Mitochondrial-targeted peptides ship primarily to research labs studying OXPHOS, ROS biology, and mitochondrial dysfunction in disease models. The lipophilic / cationic character that drives mitochondrial accumulation also makes these peptides somewhat oxidation-prone in solution, working stocks should be prepared fresh or held at -80 °C rather than -20 °C when the workflow permits.
Primary buyer fit: academic and contract research laboratories and 503A / 503B compounding pharmacies.
Specifications
Also available as a nasal spray (US stock)
Besides lyophilized vials, SS-31 / Elamipretide is stocked in the US as a ready-to-use nasal spray.
Documentation available on request
Each picture is a low-resolution preview of a report's first page, with batch and report numbers covered. For the full, clear report, ask our sales team, naming the product and strength.
Batch COASS-31 / Elamipretide 5 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Batch COASS-31 / Elamipretide 10 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Batch COASS-31 / Elamipretide 50 mg
HPLC purity · MS identity
Batch COA
Full, clear copy from sales
Third-party reportSS-31 50 mg
HPLC purity · MS identity
Third-party laboratory, Tianjin, China
Full, clear copy from sales
Independent test fails? Full refund. How it works
Regulatory note
Sold for research use only. Not approved as a drug product in any jurisdiction at the time of shipment. For in vivo studies, the buyer can ask sales to scope bacterial-endotoxin and microbial-limit testing when its written procedure requires those results.
Selected literature
Frequently asked questions
The Dmt (2',6'-dimethyl-L-tyrosine) at position 2 is critical to SS-31's biological activity for two reasons. First, the additional methyl groups increase the aromatic π-electron density and the hydrophobic surface area, both of which contribute to the cationic-aromatic motif that drives mitochondrial accumulation and cardiolipin binding. Second, Dmt is resistant to the aminopeptidase cleavage that would degrade the natural-Tyr analog, giving SS-31 a longer functional half-life in plasma and intracellular compartments. The natural-Tyr analog is a useful negative control in research but is not biologically equivalent.
SS-31's selectivity for mitochondrial accumulation comes from the combination of its overall +3 net cationic charge at physiological pH plus the aromatic / hydrophobic groups (Dmt and Phe). The inner mitochondrial membrane has a strongly negative trans-membrane potential (-180 mV in healthy cells), which drives the accumulation of cationic-aromatic molecules by 100- to 1000-fold over cytoplasmic concentration. SS-31 differs from earlier mitochondria-targeted compounds (like the TPP-conjugates) in that the targeting is built into the peptide backbone itself rather than added as a separate triphenylphosphonium cation, which gives more predictable pharmacokinetics and lower off-target effects on other membrane potentials.
Yes. SS-31 / Elamipretide is also stocked as a ready-to-use nasal spray (5 mg) in 10 mL or 20 mL bottles, from 10 bottles of each. These orders ship from our US stock; ask our sales team for details and a quote.
Send any vial from your order to an independent laboratory of your choice. If the report shows the product does not meet the specification on its COA — purity below the stated minimum, or an identity that does not match — share the report with our sales team and we refund that product in full.
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