What's on the label is the measured result — net peptide mass, not gross powder weight, plus RP-HPLC purity, on a lot-numbered COA for every batch.
Net peptide mass and RP-HPLC purity — a lot-numbered COA for every batch.
Net peptide mass + HPLC purity, per lot.
PCAC will review 7 peptides for the 503A bulks list, BPC-157, KPV, TB-500, MOTS-c, Emideltide, Semax, Epitalon. Read our briefing →
PCAC will review 7 peptides for the 503A bulks list. Read →
FDA PCAC reviews 7 peptides in July. Read →
Mitochondrial-derived cytoprotective 24-mer peptide
Overview
Humanin was the first mitochondrial-derived peptide (MDP) to be described — encoded not in the nuclear genome but within the mitochondrial 16S rRNA (MT-RNR2) region. It was discovered through screens for factors that protect neurons against Alzheimer's-associated toxicity, and the research field around it centers on cytoprotection, apoptosis suppression, and metabolic signaling, positioning humanin alongside MOTS-c as a founding member of the mitochondrial-derived-peptide class. The commonly studied form is the 24-residue cytosolic sequence. PeptideXpo supplies humanin as a lyophilized powder at ≥ 98% HPLC. Researchers should note that several potency-enhanced analogs exist — most notably the S14G variant (HNG, 'Humanin-G'), reported to be dramatically more potent than wild-type in cytoprotection assays — so specifying wild-type versus HNG matters when comparing results across the literature. The peptide contains a cysteine (Cys8); prepare under conditions that limit oxidation, aliquot, and store frozen. Supplied in 10 mg fills as a research reference material only.
Who buys this, and why
Mitochondrial-targeted peptides ship primarily to research labs studying OXPHOS, ROS biology, and mitochondrial dysfunction in disease models. The lipophilic / cationic character that drives mitochondrial accumulation also makes these peptides somewhat oxidation-prone in solution, working stocks should be prepared fresh or held at -80 °C rather than -20 °C when the workflow permits.
Primary buyer fit: academic and contract research laboratories.
Specifications
Documentation available on request
Regulatory note
Research-use-only reference material; not for human or veterinary use.
Selected literature
Frequently asked questions
Mitochondrial-derived peptides (MDPs) are small peptides encoded within the mitochondrial genome rather than nuclear DNA — a discovery that expanded the known coding capacity of mitochondria. Humanin was the first MDP identified (in the MT-RNR2 16S rRNA region) and established the concept; MOTS-c followed. The class is studied for retrograde mitochondria-to-nucleus signaling, cytoprotection, and metabolic regulation, which is why humanin is a reference tool in mitochondrial and longevity research.
HNG, or Humanin-G, carries a single serine-to-glycine substitution at position 14. That one change makes it substantially more potent than wild-type humanin in cytoprotection assays, which is why much of the in vitro and in vivo literature uses HNG rather than the native sequence. When comparing published results, check which form was used — the potency gap is large enough to change conclusions. PeptideXpo's standard SKU is wild-type; HNG is available on request.
